Genetic risk factors and candidate biomarkers for Alzheimer s disease

Genetic risk factors and candidate biomarkers for Alzheimer's disease.

Alzheimer's disease is a multifactorial and progressive neurodegenerative disease, extremely diffused and with an increasing prevalence worldwide. There is an urgent need for biomarkers to diagnose AD early in its course. Furthermore, accurate biomarkers would be able to determine the clinical efficacy of novel neuroprotective strategies. Although the heritability of late-onset AD is high, our ...

Alzheimer disease: epidemiology, diagnostic criteria, risk factors and biomarkers.

The global prevalence of dementia is as high as 24 million, and has been predicted to quadruple by the year 2050. In the US alone, Alzheimer disease (AD) - the most frequent cause of dementia characterized by a progressive decline in cognitive function in particular the memory domain - causes estimated health-care costs of $ 172 billion per year. Key neuropathological hallmarks of the AD brain ...

Proteomic Biomarkers in Alzheimer s disease

Alzheimer’s disease (AD) is a major problem of health in developed countries. From a pathogenic perspective, this prevalent form of dementia is a polygenic/complex disorder in which over 600 defective genes distributed across the human genome may be involved, in conjunction with epigenetic aberrations and diverse environmental risk factors [1]. The abnormal expression of genes and subsequent po...

Identification and Functional Characterization of Genetic Risk Factors in Alzheimer ́s Disease

The most valuable biomarkers of Alzheimer\'s disease: a review article

Alzheimer’s disease (AD) is the most popular type of dementia in elderly and is described by a progressive loss of cognitive capacity and severe neurodegeneration which typically begins with memory deficits. The major biomarkers of AD include total tau, phosphorylated-tau and 42 amino acid isoform of amyloid beta that reflect neurodegeneration and indicate the pathophysiological processes in AD...